Rovers created a few early half chances but it was in fact the home side who took the lead in the 12th minute when Mark Weir was guilty of a foul in the Carluke box and a penalty was awarded which was converted for 1-0 to Renfrew.
Carluke tries to claw themselves back in to the match but the attacking speed they rely on did not seem to be causing the Renfrew defence problems until they finally managed to get a couple of balls across goal from wide areas but unfortunately both went harmlessly wide.
The 32nd minute saw Weir with a chance to make up for the penalty but his free kick from all of 30 yards went just over the Renfrew cross bar.
Renfrew had a golden chance to double their lead in 38 mins when a poor Carluke clearance set them free on goal but the chance was blazed well over the bar.
Rovers would have loved to get on level terms before playing down the Keanie park slope in the second half and almost managed this in 39 mins when a good move on the left ended with Ian Watt putting a low ball across goal where Gordon Murphy poked the ball goalwards but a last ditch clearance prevented the score.
The second half saw Carluke patient in the build up as they tried to get back on level terms and they won a corner in 53 mins after a good challenge from Jonny Wilson, the flag kick was put in by Weir and was met by the head of Craig Stark and his effort gave the home keeper no chance as it found the net for 1-1.
The celebrations had barely died for Carluke when they started again in the 55th min, a poor clearance was pounced on by Watt who beat three defenders before hitting a shot which took a slight deflection before ending in the Renfrew net for 2-1 to the visitors.
Renfrew huffed and puffed as they tried to get on level terms and a low cross was cleared at the back post by Daniel Kindlan in the 70th min, but the closest they came was a few minutes later when a good cross found a Renfrew head and with the effort looking net bound it took a good save by Jonny Grier in the Rovers goal to keep them in front.
The points were wrapped up in the 80th min with a sublime goal when Murphy played a ball forward for Ryan Smillie to chase and he outstripped his marker before putting a perfect ball in to the path of Watt with the strikers excellent controlling touch setting him in on goal and he left his marker in his wake before striking a low shot in to the Renfrew net for 3-1.
The visiting Rovers defence were a match for anything Renfrew threw at them for the remainder of the match and Carluke went on to collect another 3 league points.
Grier, Lithgow, Souter, Gow, Stark, Dan Kindlan, Wilson, Murphy, Weir, Watt, Smillie.
Subs. Dickson for Weir, Stewart for Lithgow, Ferguson for Smillie